Beilstein J. Nanotechnol.2020,11, 263–284, doi:10.3762/bjnano.11.20
possibility of detecting genetic mutations rapidly in physiological media through liquidbiopsy has attracted the attention within the materials science community. The physical properties of nanoparticles combined with robust transduction methods ensure an improved sensitivity and specificity of a given assay
simple blood test, setting thus a milestone of “liquidbiopsy”. Liquidbiopsy has the potential to accelerate the early cancer diagnosis by the detection of biomolecules such as cell-fee DNA directly in blood samples.
Currently, the development of liquid biopsies is directly linked to the state-of-the
techniques are without parallel in the analysis of genetic material and the detection of mutations, they require an operation by specialized personnel in large infrastructures such as hospitals or research centers. The democratization of liquidbiopsy and therefore the advancement of personal medicine needs
PDF
Figure 1:
Alterations in cell-free DNA. Cell-free DNA can be released from both cancerous and normal cells lo...
Beilstein J. Nanotechnol.2016,7, 364–373, doi:10.3762/bjnano.7.33
.
Keywords: biophotonics; breast cancer; iron/iron oxide nanoparticle; liquidbiopsy; nanodiagnostics detection; nanomedicine; sub-femtomolar limit of detection; Introduction
We have detected stage I breast cancer in human patients with statistical significance by means of a simple serum test using highly
-care diagnostics, it is still more than minimally invasive, because the nanoworms have to be given intravenously. An ideal “liquidbiopsy” [30] will require only the drawing of a simple blood sample to detect cancer, without introducing a reagent to the patient’s body first. In this report, we would
always when testing biomarkers, the selection process of the required biospecimens is crucial. Therefore, our next steps will consist in testing our liquidbiopsy approach with significantly larger group sizes of stage 0 and I breast cancer patients.
Methods
Nanoplatform synthesis
The synthesis and
PDF
Figure 1:
Nanosensors for in vitro protease detection. For each protease, a highly selective oligopeptide is ...